Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II.

@article{Chen1994AbnormalFR,
  title={Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II.},
  author={Chiping Chen and Donald G. Rainnie and Robert W Greene and Susumu Tonegawa},
  journal={Science},
  year={1994},
  volume={266 5183},
  pages={291-4}
}
Mice deficient for the gene encoding alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII knockout mice) provide a promising tool to link behavioral and cellular abnormalities with a specific molecular lesion. The heterozygous mouse exhibited a well-circumscribed syndrome of behavioral abnormalities, consisting primarily of a decreased fear response and an increase in defensive aggression, in the absence of any measured cognitive deficits. Unlike the heterozygote, the homozygote displayed… CONTINUE READING