Abnormal fatty acid composition in the frontopolar cortex of patients with affective disorders

@inproceedings{Tatebayashi2012AbnormalFA,
  title={Abnormal fatty acid composition in the frontopolar cortex of patients with affective disorders},
  author={Yoshitaka Tatebayashi and Naomi Nihonmatsu-Kikuchi and Yoshihito Hayashi and Xiu-jun Yu and Miho Soma and Kazutaka Ikeda},
  booktitle={Translational Psychiatry},
  year={2012}
}
Bipolar and major depressive disorders are essentially relapsing and remitting disorders of affect with nearly full recovery between episodes. Although the underlying molecular mechanisms remain unclear, myelin-related abnormalities have long been suspected. Here, using novel statistical analysis, we show that subtle but significant abnormalities exist in the composition of fatty acids (FAs), including docosapentaenoic acid (22:5n-3), one of the omega-3 polyunsaturated FAs, found in the post… CONTINUE READING
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