Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.

@article{Liu2011AbnormalEO,
  title={Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.},
  author={Yun Liu and Hong Jiang and Ling-yun He and Wu-jian Huang and Xiao-yu He and Fu-qi Xing},
  journal={Reproduction, fertility, and development},
  year={2011},
  volume={23 4},
  pages={520-6}
}
Polycystic ovary syndrome (PCOS) may result from hypersensitivity to insulin, which is negatively regulated by uncoupling protein (UCP)-2. Because cholesterol side-chain cleavage enzyme (CYP11A1) is closely linked to PCOS, the expression of UCP-2 and CYP11A1 in ovarian tissues from PCOS patients was examined in the present study. Twelve PCOS patients with hyperandrogenaemia who underwent laparoscopic ovarian wedge resection and 12 age-matched control patients who underwent contralateral ovarian… CONTINUE READING