Abnormal expression of the ERG transcription factor in prostate cancer cells activates osteopontin.

@article{Flajollet2011AbnormalEO,
  title={Abnormal expression of the ERG transcription factor in prostate cancer cells activates osteopontin.},
  author={S{\'e}bastien Flajollet and Tian V. Tian and Anne Flourens and Nathalie Tomavo and Arnauld Villers and Edith Bonnelye and S{\'e}bastien Aubert and Xavier Leroy and Martine Duterque-Coquillaud},
  journal={Molecular cancer research : MCR},
  year={2011},
  volume={9 7},
  pages={914-24}
}
Osteopontin (OPN) is an extracellular matrix glycophosphoprotein that plays a key role in the metastasis of a wide variety of cancers. The high level of OPN expression in prostate cells is associated with malignancy and reduced survival of the patient. Recent studies on prostate cancer (PCa) tissue have revealed recurrent genomic rearrangements involving the fusion of the 5' untranslated region of a prostate-specific androgen-responsive gene with a gene coding for transcription factors from the… CONTINUE READING

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The nature and significance of osteopontin. Connective tissue research 1989;23(2-3):123-36

  • WT Butler
  • 1989
Highly Influential
4 Excerpts

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