Abnormal expression of laminin suggests disturbance of sarcolemma-extracellular matrix interaction in Japanese patients with autosomal recessive muscular dystrophy deficient in adhalin.

@article{Higuchi1994AbnormalEO,
  title={Abnormal expression of laminin suggests disturbance of sarcolemma-extracellular matrix interaction in Japanese patients with autosomal recessive muscular dystrophy deficient in adhalin.},
  author={Itsuro Higuchi and Hitoshi Yamada and Hidetoshi Fukunaga and Hideaki Iwaki and Ryuichi Okubo and Masanori Nakagawa and Mitsuhiro Osame and Steven L. Roberds and Teruo Shimizu and Kevin P Campbell},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={94 2},
  pages={601-6}
}
Dystrophin is associated with several novel sarcolemmal proteins, including a laminin-binding extracellular glycoprotein of 156 kD (alpha-dystroglycan) and a transmembrane glycoprotein of 50 kD (adhalin). Deficiency of adhalin characterizes a severe autosomal recessive muscular dystrophy prevalent in Arabs. Here we report for the first time two mongoloid… CONTINUE READING