Abnormal expression of MDM-2 in breast carcinomas

  title={Abnormal expression of MDM-2 in breast carcinomas},
  author={Carlos E Bueso-Ramos and Taghi Manshouri and Mohammad A. Haidar and Yun Yang and Patrick McCown and Nelson Ordonez and Armand Glassman and Nour Sneige and Maher Albitar},
  journal={Breast Cancer Research and Treatment},
MDM-2 is a cellular oncoprotein that binds to the p53 protein and abrogates its growth-suppressing function. At least seven MDM-2 mRNAs and five proteins (p90, p85, p76, p74, and p57) have been reported in tissue culture. MDM-2 gene amplification occurs in human sarcomas and high-grade gliomas. MDM-2 overexpression without gene amplification has been reported in leukemias and lymphomas. Here we report MDM-2 mRNA overexpression in 24 (73%) out of 33 cases of human breast carcinoma as compared… CONTINUE READING

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Publications referenced by this paper.
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Overexpression of the MDM-2 gene is found in some cases of haematological malignancies

B Quesnel, C Preudhomme, +4 authors P Fenaux
Br J Haematol • 1994
View 1 Excerpt

Clinical implications of the p53 tumor-suppressor gene.

The New England journal of medicine • 1993
View 2 Excerpts

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