Abnormal expression of FLI 1 protein is an adverse prognostic factor in acute myeloid leukemia

@inproceedings{Kornblau2011AbnormalEO,
  title={Abnormal expression of FLI 1 protein is an adverse prognostic factor in acute myeloid leukemia},
  author={Steven M. Kornblau and Ying-he Qiu and Nianxiang Zhang and Neera Singh and Stefan Faderl and Alessandra Ferrajoli and Heather P. York and Amina Qutub and Kevin R. Coombes and Dennis K. Watson},
  year={2011}
}
Friend leukemia virus integration 1 (FLI1), an Ets transcription factor family member, is linked to acute myelogenous leukemia (AML) by chromosomal events at the FLI1 locus, but the biologic impact of FLI1 expression on AML is unknown. FLI1 protein expression was measured in 511 newly diagnosed AML patients. Expression was similar in peripheral blood (PB) and BM and higher at diagnosis than at relapse (P .02). Compared with normal CD34 cells, expression in AML was above or below normal in 32… CONTINUE READING

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