Abnormal expression of ADAR1 isoforms in Chinese pediatric acute leukemias.

@article{Ma2011AbnormalEO,
  title={Abnormal expression of ADAR1 isoforms in Chinese pediatric acute leukemias.},
  author={Cui-Hua Ma and Jing-hui Chong and Y. P. Guo and Hui-min Zeng and Shu-yan Liu and Lin-lin Xu and Jia Wei and Y Lin and Xiaofan Zhu and Guoguang Zheng},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={406 2},
  pages={245-51}
}
The posttranscriptional RNA editing by the type 1 adenosine deaminase acting on RNAs (ADAR1), expressed as p110 and p150 isoforms, is important for both physiological and pathological processes. Their expression and significance in leukemias remain unknown. Here, we investigated the expression of ADAR1 in Chinese pediatric acute leukemias by real-time PCR and Western blot. The results showed that significant high expression of p110 was detected in leukemias, especially in B-ALL, whereas a… CONTINUE READING