Abnormal excitability of premotor-motor connections in de novo Parkinson's disease.

@article{Buhmann2004AbnormalEO,
  title={Abnormal excitability of premotor-motor connections in de novo Parkinson's disease.},
  author={Carsten Buhmann and A. Gorsler and Tobias B{\"a}umer and U Hidding and Cueneyt Demiralay and Kim Hinkelmann and Cornelius Weiller and Hartwig R. Siebner and Alexander M{\"u}nchau},
  journal={Brain : a journal of neurology},
  year={2004},
  volume={127 Pt 12},
  pages={2732-46}
}
The dorsal premotor cortex (PMd) is abnormally active in patients with idiopathic Parkinson's disease. This has been interpreted as a functional correlate of adaptive plasticity within the motor system to compensate for deficient activation of striato-mesial-frontal projections in these patients. Whether abnormal PMd activity influences excitability in the primary motor cortex (M1) in untreated Parkinson's disease patients and how this premotor-motor interaction might be altered by l-dopa is… CONTINUE READING
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