Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease.

@article{Nakamura1991AbnormalDO,
  title={Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease.},
  author={Yuka Nakamura and Masatoshi Takeda and Hiko Suzuki and Hiroaki Hattori and Keiya Tada and Shiro Hariguchi and Shigeo Hashimoto and Tomoko Nishimura},
  journal={Neuroscience letters},
  year={1991},
  volume={130 2},
  pages={195-8}
}
Formalin-fixed paraffin-embedded hippocampal sections of brains with early-onset and late-onset Alzheimer's disease were studied immunohistochemically with antisera against cathepsin D and cathepsin B. In addition to the staining of neuronal perikarya, some of the senile plaques visualized by Bielshowsky silver staining and some of reactive astrocytes were positively stained with the antisera against cathepsin D and cathepsin B in brains with Alzheimer's disease. Abnormal localization of… CONTINUE READING

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