Abnormal differentiation of erythroid precursors in p45 NF-E2(-/-) mice.

@article{Gasiorek2012AbnormalDO,
  title={Abnormal differentiation of erythroid precursors in p45 NF-E2(-/-) mice.},
  author={Jadwiga J. Gasiorek and Zaynab Nouhi and Volker Blank},
  journal={Experimental hematology},
  year={2012},
  volume={40 5},
  pages={393-400}
}
The transcription factor p45 nuclear factor-erythroid-derived 2 (NF-E2) plays major roles in erythroid and megakaryocytic lineages. Here, we investigated the role of p45 NF-E2 in erythroid differentiation in vivo. Absence of p45 NF-E2 in mice leads to a twofold increase in serum erythropoietin levels. In the bone marrow of these animals, we found a different distribution of precursor populations compared to wild-type mice, suggesting abnormal differentiation. Loss of p45 NF-E2 was also… CONTINUE READING

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