Abnormal developmental control of replication-timing domains in pediatric acute lymphoblastic leukemia.

@article{Ryba2012AbnormalDC,
  title={Abnormal developmental control of replication-timing domains in pediatric acute lymphoblastic leukemia.},
  author={Tyrone Ryba and Dana Battaglia and Bill H Chang and James W. Shirley and Quinton Buckley and Benjamin D. Pope and Meenakshi Devidas and Brian J. Druker and David M. Gilbert},
  journal={Genome research},
  year={2012},
  volume={22 10},
  pages={1833-44}
}
Abnormal replication timing has been observed in cancer but no study has comprehensively evaluated this misregulation. We generated genome-wide replication-timing profiles for pediatric leukemias from 17 patients and three cell lines, as well as normal B and T cells. Nonleukemic EBV-transformed lymphoblastoid cell lines displayed highly stable replication-timing profiles that were more similar to normal T cells than to leukemias. Leukemias were more similar to each other than to B and T cells… CONTINUE READING
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