Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice.

@article{Alimzhanov1997AbnormalDO,
  title={Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice.},
  author={Marat B. Alimzhanov and Dmitry V Kuprash and Marie H. Kosco-Vilbois and A. {\'A}lvarez Luz and Regina L. Turetskaya and Alexander Tarakhovsky and Klaus Rajewsky and S. A. Nedospasov and Klaus Pfeffer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 17},
  pages={
          9302-7
        }
}
The tumor necrosis factor (TNF) family cytokines lymphotoxin (LT) alpha and LTbeta form heterotrimers that are expressed on the surface of activated lymphocytes and natural killer cells; LTalpha homotrimers can be secreted as well. Mice with a disrupted LTalpha gene lack lymph nodes (LN), Peyer's patches (PP), and follicular dendritic cell (FDC) networks and reveal profound defects of the splenic architecture. However, it is unclear which of these abnormalities is the result of the absence in… CONTINUE READING

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References

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SHOWING 1-3 OF 3 REFERENCES

Alimzhanov et al

A. Kratz, A. Campos-Neto, +3 authors 1461–1472. Immunology
  • Proc. Natl. Acad. Sci. USA 94
  • 1997
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Alimzhanov et al

C. F. Ware, P. D. Crowe, +9 authors 3100. 9306 Immunology
  • Proc. Natl. Acad. Sci. USA 94
  • 1997

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