Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2.

@article{Vadasz2005AbnormalDO,
  title={Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2.},
  author={Zehava Vadasz and Ofra Kessler and Gal Akiri and Stela Gengrinovitch and Herbert M. Kagan and Yaacov Baruch and Ofer Ben Izhak and Gera Neufeld},
  journal={Journal of hepatology},
  year={2005},
  volume={43 3},
  pages={499-507}
}
BACKGROUND/AIMS Lysyl-oxidases catalyze the oxidation of lysine residues in collagen and elastin thereby promoting their polymerization. We have studied here the expression of four lysyl-oxidases in normal and diseased human liver. METHODS The expression of the different lysyl-oxidases in paraffin embedded liver sections was studied using in-situ hybridization and immunohistochemistry. The enzymatic activity of lysyl-oxidase like protein-2 (Loxl2 or LOR-1) using a previously described lysyl… CONTINUE READING

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