Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits.

@article{Comery1997AbnormalDS,
  title={Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits.},
  author={Thomas A. Comery and Jennifer Busch Harris and Patrick J. Willems and Ben A. Oostra and Scott A Irwin and Ivan Jeanne Weiler and William T. Greenough},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 10},
  pages={5401-4}
}
Fragile X syndrome arises from blocked expression of the fragile X mental retardation protein (FMRP). Golgi-impregnated mature cerebral cortex from fragile X patients exhibits long, thin, tortuous postsynaptic spines resembling spines observed during normal early neocortical development. Here we describe dendritic spines in Golgi-impregnated cerebral cortex… CONTINUE READING