Abnormal dark adaptation kinetics in autosomal dominant sector retinitis pigmentosa due to rod opsin mutation.

@article{Moore1992AbnormalDA,
  title={Abnormal dark adaptation kinetics in autosomal dominant sector retinitis pigmentosa due to rod opsin mutation.},
  author={Anthony T Moore and Frederick W. Fitzke and Colin M. Kemp and Geoffrey B. Arden and T. Jeffrey Keen and Chris F. Inglehearn and Shomi Shanker Bhattacharya and Alan C. Bird},
  journal={The British journal of ophthalmology},
  year={1992},
  volume={76 8},
  pages={
          465-9
        }
}
The time course of dark adaptation was measured in 10 subjects from three families with autosomal dominant sector retinitis pigmentosa (RP) due to mutations in the first exon of the rod opsin gene. In each subject cone adaptation and the early part of the recovery of rod sensitivity followed the normal time course, but the later phase of rod adaptation was markedly prolonged. The recovery of rod sensitivity is much slower than that reported in any other outer retinal dystrophy. Using a model… CONTINUE READING
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Autosomal dominant retinitis pigmentosa : four mutations in rhodopsin , one ofthem at the retinal attachment site

TJ Keen, CF Inglehearn, +3 authors AC Bird
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Phenotypic expression of the Pro 23 His mutation of rhodopsin in a large family with autosomal dominant retinitis pigmentosa

RG Weleber, WH Murphey, +3 authors SP Daiger
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