Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation.

@article{Miller2001AbnormalCF,
  title={Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation.},
  author={Todd F. Miller and Danuta Szczęsna and Philippe R. Housmans and Jiaju Zhao and Fenna de Freitas and Aldrin V Gomes and Lieneke Cecile Culbreath and Joan Mccue and Ying Wang and Yuanyuan Xu and W. Glenn L. Kerrick and James D. Potter},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 6},
  pages={
          3743-55
        }
}
This study characterizes a transgenic animal model for the troponin T (TnT) mutation (I79N) associated with familial hypertrophic cardiomyopathy. To study the functional consequences of this mutation, we examined a wild type and two I79N-transgenic mouse lines of human cardiac TnT driven by a murine alpha-myosin heavy chain promoter. Extensive characterization of the transgenic I79N lines compared with wild type and/or nontransgenic mice demonstrated: 1) normal survival and no cardiac… CONTINUE READING
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