Abnormal connexin expression underlies delayed wound healing in diabetic skin.

@article{Wang2007AbnormalCE,
  title={Abnormal connexin expression underlies delayed wound healing in diabetic skin.},
  author={Chiuhui Mary Wang and J. L. Lincoln and Jeremy Cook and David Laurence Becker},
  journal={Diabetes},
  year={2007},
  volume={56 11},
  pages={2809-17}
}
OBJECTIVE Dynamically regulated expression of the gap junction protein connexin (Cx)43 plays pivotal roles in wound healing. Cx43 is normally downregulated and Cx26 upregulated in keratinocytes at the edge of the wound as they adopt a migratory phenotype. We have examined the dynamics of Cx expression during wound healing in diabetic rats, which is known to be slow. RESEARCH DESIGN AND METHODS We induced diabetes with streptozotocin and examined Cx expression and communication in intact and… CONTINUE READING