Abnormal concentrations of esterified carnitine in bile: a feature of pediatric acute liver failure with poor prognosis.

@article{Shneider2005AbnormalCO,
  title={Abnormal concentrations of esterified carnitine in bile: a feature of pediatric acute liver failure with poor prognosis.},
  author={Benjamin L Shneider and Piero Rinaldo and Sukru H. Emre and J C Bucuvalas and Robert Squires and Michael L. Narkewicz and Gabriel E Gondolesi and Margret Magid and Raffaella A Morotti and Linda S. Hynan},
  journal={Hepatology},
  year={2005},
  volume={41 4},
  pages={717-21}
}
The etiology of acute liver failure in children is unknown in a large number of cases. Defects in fatty acid oxidation have been shown to lead to severe liver injury. This retrospective analysis examined the bile acylcarnitine profiles of 27 children with acute liver failure who underwent liver transplantation or died. Results were compared with 758 postmortem samples from individuals without acute liver failure. Cumulative amounts of free carnitine, medium- or long-chain species in excess of… CONTINUE READING