Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy.

@article{Merkl2011AbnormalCA,
  title={Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy.},
  author={Angela Merkl and Florian Schubert and Arnim Quante and Alexander Luborzewski and Eva-Lotta Brakemeier and Simone Grimm and Isabella Heuser and Malek Bajbouj},
  journal={Biological psychiatry},
  year={2011},
  volume={69 8},
  pages={772-9}
}
BACKGROUND Metabolic changes after electroconvulsive therapy (ECT) have been described in depressed patients, but results are heterogeneous. To determine the concentrations of N-acetyl-aspartate (NAA), choline-containing compounds, creatine + phosphocreatine (tCr), and glutamate in the left dorsolateral prefrontal cortex (DLPFC) and left anterior cingulum of depressed patients before and after ECT, we used proton magnetic resonance spectroscopy. METHODS Metabolite concentrations in the DLPFC… CONTINUE READING