Abnormal cerebral perfusion in chronic methamphetamine abusers: A study using 99mTC-HMPAO and spect

  title={Abnormal cerebral perfusion in chronic methamphetamine abusers: A study using 99mTC-HMPAO and spect},
  author={Masaomi Iyo and Hiroki Namba and Masamichi Yanagisawa and Shinji Hirai and Nobuharu Yui and Susumu Fukui},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • M. Iyo, H. Namba, S. Fukui
  • Published 1 July 1997
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
Abnormal cerebral blood flow in methamphetamine abusers assessed by brain perfusion single emission computed tomography
It is shown that amphetamine abuse can induce diffuse and nonhomogeneous disorders of brain perfusion which was more prominent in the right hemisphere.
Emission Tomographic Studies in Substance Abuse
Computer-based advances in computational and data processing capacity have led to the development of tomographic techniques such as positron emission tomography (PET) and single photon emission computed tomographic (SPECT) and the ability to non-invasively measure regional CBF and cerebral blood volume.
Perfusion Magnetic Resonance Imaging in Psychiatry
  • J. Théberge
  • Medicine, Psychology
    Topics in magnetic resonance imaging : TMRI
  • 2008
This article aims to review the existing literature on applications of perfusion MRI in psychiatric disorder and substance abuse research and provides a brief introductory overview of dynamic susceptibility contrast MRI and arterial spin labeling techniques.
Neuroimaging in Chronic MAP Users
Four major findings are presented, by using neuroimaging techniques, in the brain of chronic MAP users: significant and persistent reductions in dopamine transporter (DAT) density, which were correlated with both the duration of MAP use and severity of psychotic symptoms, and reversible changes in D2 receptors.
Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users
In vivo evidence for long-term CNS toxicity, associated with chronic binge use of methamphetamine.
Neuromechanism of Developing Methamphetamine Psychosis: A Neuroimaging Study
It is suggested that long‐term use of MAP causes abnormal cerebral blood flow patterns, reduction of brain dopamine transporter density, and metabolite alteration, which may be closely related to a susceptibility to MAP psychosis.
Research Peper: Brain Structure Changes Associated With Methamphetamine Abuse in Brain Magnetic Resonance Imaging
This study aimed at evaluating the structural brain changes following amphetamines abuse, using Magnetic Resonance Imaging (MRI).
Structural Abnormalities in the Brains of Human Subjects Who Use Methamphetamine
MRI-based maps suggest that chronic methamphetamine abuse causes a selective pattern of cerebral deterioration that contributes to impaired memory performance, and brain substrates may help account for the symptoms of MA abuse, providing therapeutic targets for drug-induced brain injury.
CHAPTER 8 – Imaging


Cerebral abnormalities in cocaine abusers: demonstration by SPECT perfusion brain scintigraphy. Work in progress.
Among the findings were scattered focal cortical deficits, which were seen in several patients and which ranged in severity from small and few to multiple and large, with a special predilection for the frontal and temporal lobes.
Brain perfusion is abnormal in cocaine-dependent polydrug users: a study using technetium-99m-HMPAO and ASPECT.
This study studied a group of cocaine-dependent polydrug users with 99mTc-HMPAO and high-resolution SPECT and compared their perfusion pattern to cerebral perfusion in an older control subjects, finding abnormal perfusion characterized primarily as small focal defects involving inferoparietal, temporal, and anterofrontal cortex and basal ganglia.
Cerebral Blood Flow in Chronic Cocaine Users: A Study with Positron Emission Tomography
It is hypothesised that some of the widespread defects in CBF in the cocaine users could reflect the effects of vasospasm in cerebral arteries exposed chronically to the sympathomimetic actions of cocaine.
[Intracerebral hemorrhage and characteristic angiographic changes associated with methamphetamine--a case report].
In the present case "beading" of the intracranial vessels may be related to angiitis induced by methamphetamine, and both the presence of arterial inflammation and increased blood pressure caused by sympathomimetic action of methamphetamine are probably the important factors in the occurrence of intrac Cranial hemorrhage associated with methamphetamine.
Cerebral angiographic changes in the drug abuse patient.
The cerebral angiographic findings in 19 drug abuse patients showed irregular segmental areas of constriction with changes of caliber and contour of the vessel walls, but it is possible the changes are due primarily to vasculitis and secondary thrombus formation.
Cerebral vascular changes secondary to amphetamine abuse in the experimental animal.
All 5 animals at necropsy demonstrated extensive brain damage and there were focal areas of ischemia and infarction and generalized areas of cerebral edema and ischemic nerve cell changes.
[An autopsy case of subarachnoid and intracerebral hemorrhage and necrotizing angitis associated with methamphetamine abuse].
We report an autopsy case of methamphetamine-related intracranial hemorrhage and vasculitis. The possible relationship between drug usage and the occurrence of intracranial bleeding and cerebral
Acute exacerbation of paranoid psychotic state after long-term abstinence in patients with previous methamphetamine psychosis.
The positive prophylactic effect of small doses of haloperidol on the acute exacerbation may suggest the participation of dopaminergic supersensitivity as a mechanism for the paranoid psychotic state.
[Drug addiction and drug abuse].
  • W. Feuerlein
  • Medicine
    Munchener medizinische Wochenschrift
  • 1969