Abnormal cerebral effective connectivity during explicit emotional processing in adults with autism spectrum disorder.

@article{Wicker2008AbnormalCE,
  title={Abnormal cerebral effective connectivity during explicit emotional processing in adults with autism spectrum disorder.},
  author={Bruno Wicker and Pierre Fonlupt and B{\'e}n{\'e}dicte Hubert and Carole Tardif and Bruno Gepner and Christine Deruelle},
  journal={Social cognitive and affective neuroscience},
  year={2008},
  volume={3 2},
  pages={135-43}
}
Several recent studies suggest that autism may result from abnormal communication between brain regions. We directly assessed this hypothesis by testing the presence of abnormalities in a model of the functional cerebral network engaged during explicit emotion processing in adults with high functioning autism or Asperger syndrome. Comparison of structural equation models revealed abnormal patterns of effective connectivity, with the prefrontal cortex as a key site of dysfunction. These findings… CONTINUE READING