Abnormal cerebellar cytoarchitecture and impaired inhibitory signaling in adult mice lacking TR4 orphan nuclear receptor.

@article{Chen2007AbnormalCC,
  title={Abnormal cerebellar cytoarchitecture and impaired inhibitory signaling in adult mice lacking TR4 orphan nuclear receptor.},
  author={Y Chen and Loretta L. Collins and Hideo Uno and S. M. Chou and Charles K. Meshul and Shu-Shi Chang and Chawnshang Chang},
  journal={Brain research},
  year={2007},
  volume={1168},
  pages={72-82}
}
Since testicular orphan nuclear receptor 4 (TR4) was cloned, its physiological functions remain largely unknown. In this study, the TR4 knockout (TR4(-/-)) mouse model was used to investigate the role of TR4 in the adult cerebellum. Behaviorally, these null mice exhibit unsteady gait, as well as involuntary postural and kinetic movements, indicating a disturbance of cerebellar function. In the TR4(-/-) brain, cerebellar restricted hypoplasia is severe and cerebellar vermal lobules VI and VII… CONTINUE READING