Abnormal cell properties and down-regulated FAK-Src complex signaling in B lymphoblasts of autistic subjects.

@article{Wei2011AbnormalCP,
  title={Abnormal cell properties and down-regulated FAK-Src complex signaling in B lymphoblasts of autistic subjects.},
  author={Hongen Wei and Mazhar N. Malik and Ashfaq M. Sheikh and George Merz and W Ted Brown and Xiaohong Li},
  journal={The American journal of pathology},
  year={2011},
  volume={179 1},
  pages={66-74}
}
Recent studies suggest that one of the major pathways to the pathogenesis of autism is reduced cell migration. Focal adhesion kinase (FAK) has an important role in neural migration, dendritic morphological characteristics, axonal branching, and synapse formation. The FAK-Src complex, activated by upstream reelin and integrin β1, can initiate a cascade of… CONTINUE READING