Abnormal cardiac repolarization and impulse initiation in German shepherd dogs with inherited ventricular arrhythmias and sudden death.

@article{Sosunov1999AbnormalCR,
  title={Abnormal cardiac repolarization and impulse initiation in German shepherd dogs with inherited ventricular arrhythmias and sudden death.},
  author={Eugene A. Sosunov and Evgeny P. Anyukhovsky and A Shvilkin and Motoki Hara and Susan F. Steinberg and Peter R Danilo and Michael R. Rosen and N Sydney M{\"o}ise and J. -L. M{\'e}rot and Vincent Probst and Francis Charpentier and Y Legeay and Herv{\'e} le Marec},
  journal={Cardiovascular research},
  year={1999},
  volume={42 1},
  pages={65-79}
}
OBJECTIVE We tested the hypothesis that delayed afterdepolarization (DAD)-associated rhythms in German shepherd dogs with reduced anteroseptal left ventricular (LV) sympathetic innervation derive from abnormal beta-adrenergic receptor effector coupling. METHODS AND RESULTS In anteroseptal LV midmyocardium of afflicted dogs, beta-receptor density was… CONTINUE READING