Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor.

@article{Kornblum1998AbnormalAD,
  title={Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor.},
  author={Harley Ian Kornblum and Rahel Hussain and Jane Wiesen and P{\"a}ivi J Miettinen and Shelley D Zurcher and K C Chow and Rik Derynck and Zena Werb},
  journal={Journal of neuroscience research},
  year={1998},
  volume={53 6},
  pages={697-717}
}
Stimulation of the epidermal growth factor receptor (EGF-R) produces numerous effects on central nervous system (CNS) cells in vitro including neuronal survival and differentiation, astrocyte proliferation and the proliferation of multipotent progenitors. However, the in vivo role of EGF-R is less well understood. In the present study, we demonstrate that EGF-R null mice generated on a 129Sv/J Swiss Black background undergo focal but massive degeneration the olfactory bulb, piriform cortex… CONTINUE READING