Abnormal anteroposterior and dorsoventral patterning of the limb bud in the absence of retinoids

@article{Stratford1999AbnormalAA,
  title={Abnormal anteroposterior and dorsoventral patterning of the limb bud in the absence of retinoids},
  author={Thomas Stratford and Cairine Logan and Maija H. Zile and Malcolm Maden},
  journal={Mechanisms of Development},
  year={1999},
  volume={81},
  pages={115-125}
}
We describe here how the early limb bud of the quail embryo develops in the absence of retinoids, including retinoic acid. Retinoid-deficient embryos develop to about stage 20/21, thus allowing patterns of early gene activity in the limb bud to be readily examined. Genes representing different aspects of limb polarity were analysed. Concerning the anteroposterior axis, Hoxb-8 was up-regulated and its border was shifted anteriorly whereas shh and the mesodermal expression of bmp-2 were down… CONTINUE READING

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References

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Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

Izpisua-Belmonte, J.-C, +3 authors D. Duboule
Nature 350, • 1991
View 4 Excerpts
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