Abnormal angiogenesis but intact hematopoietic potential in TGF type I receptordeficient mice

  title={Abnormal angiogenesis but intact hematopoietic potential in TGF type I receptordeficient mice},
  author={Jonas Larsson and Marie-Jos{\'e} Goumans and Lottie Jansson and Sjo {\`E} Strand and Marga A van Rooijen and Dorien Ward and Xiufeng Xu and Peter Ten Dijke and Christine L Mummery and Stefan Karlsson},
Deletion of the transforming growth factor b1 (TGF-b1) gene in mice has previously suggested that it regulates both hematopoiesis and angiogenesis. To de®ne the function of TGF-b more precisely, we inactivated the TGF-b type I receptor (TbRI) gene by gene targeting. Mice lacking TbRI die at midgestation, exhibiting severe defects in vascular development of the yolk sac and placenta, and an absence of circulating red blood cells. However, despite obvious anemia in the TbRI ±/± yolk sacs… CONTINUE READING
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Received October

Received October • 2000

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