Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice.

@article{Larsson2001AbnormalAB,
  title={Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice.},
  author={J I R Larsson and Marie Jose T. H. Goumans and Lottie Jansson Sj{\"o}strand and Marga A van Rooijen and Dan A Ward and Per Lev{\'e}en and Xueping Xu and Peter Ten Dijke and Christine L Mummery and Stefan Karlsson},
  journal={The EMBO journal},
  year={2001},
  volume={20 7},
  pages={1663-73}
}
Deletion of the transforming growth factor beta1 (TGF-beta1) gene in mice has previously suggested that it regulates both hematopoiesis and angiogenesis. To define the function of TGF-beta more precisely, we inactivated the TGF-beta type I receptor (TbetaRI) gene by gene targeting. Mice lacking TbetaRI die at midgestation, exhibiting severe defects in… CONTINUE READING