Abnormal adherence of sickle erythrocytes to cultured vascular endothelium: possible mechanism for microvascular occlusion in sickle cell disease.

@article{Hebbel1980AbnormalAO,
  title={Abnormal adherence of sickle erythrocytes to cultured vascular endothelium: possible mechanism for microvascular occlusion in sickle cell disease.},
  author={Robert P. Hebbel and O. Yamada and Charles F. Moldow and Harry S. Jacob and James Gardiner White and JohnW. Eaton},
  journal={The Journal of clinical investigation},
  year={1980},
  volume={65 1},
  pages={
          154-60
        }
}
The abnormal shape and poor deformability of the sickled erythrocyte (RBC) have generally been held responsible for the microvascular occlusions of sickle cell disease. However, there is no correlation between the clinical severity of this disease and the presence of sickled RBC. In searching for additional factors that might contribute to the pathophysiology of sickle cell disease, we have investigated the possibility that sickle RBC might be less than normally repulsive of the vascular… CONTINUE READING

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