Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.

@article{Biancotto2007AbnormalAA,
  title={Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.},
  author={Ang{\'e}lique Biancotto and J C Grivel and Sarah J Iglehart and Christophe Vanpouille and Andrea Lisco and Scott F. Sieg and Robert L. Debernardo and Kristen G{\`a}rate and Benigno Rodr{\'i}guez and Leonid B. Margolis and Michael M. Lederman},
  journal={Blood},
  year={2007},
  volume={109 10},
  pages={4272-9}
}
There is growing recognition that HIV-1 infection leads to an activation of the immune system that includes perturbations of cytokine expression, redistribution of lymphocyte subpopulations, cell dysfunction, and cell death. Here, we explored the relationships between HIV-1 infection and immune activation in chronically HIV-1-infected human lymph nodes. In addition to CD4 T-cell depletion, we found increased effector T-cell frequencies associated with profound up-regulation of an activation… CONTINUE READING