Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

Abstract

Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus of young (4- to 6-month-old) PS1M146L/APP751SL mice model, as the initial degenerative process underlying functional disturbance prior to… (More)
DOI: 10.1007/s00401-011-0896-x

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@inproceedings{SnchezVaro2011AbnormalAO, title={Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus}, author={Raquel S{\'a}nchez-Varo and Laura Trujillo-Estrada and Elisabeth S{\'a}nchez-Mej{\'i}as and Manuel Torres and David Baglietto-Vargas and In{\'e}s Moreno-Gonz{\'a}lez and Vanessa C de Castro and Sebasti{\'a}n Jim{\'e}nez and Diego Ruano and Marisa Vizuete and Jos{\'e} Carlos D{\'a}vila and Jos{\'e} Manuel Garc{\'i}a-Verdugo and Antonio Jes{\'u}s Jim{\'e}nez and Javier Vitorica and Antonia Gutierrez}, booktitle={Acta Neuropathologica}, year={2011} }