Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.

@article{Schiebel1997AbnormalXI,
  title={Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.},
  author={Katrin Schiebel and Martina Winkelmann and Annelyse Mertz and Xiaolei Xu and David C. Page and D. Weil and Christine Petit and Gudrun A Rappold},
  journal={Human molecular genetics},
  year={1997},
  volume={6 11},
  pages={1985-9}
}
XX males and XY females have a sex reversal disorder which can be caused by an abnormal interchange between the X and the Y chromosomes. We have isolated and characterized a novel gene on the Y chromosome, PRKY. This gene is highly homologous to a previously isolated gene from Xp22.3, PRKX, and represents a member of the cAMP-dependent serine threonine protein kinase gene family. Abnormal interchange can occur anywhere on Xp/Yp proximal to SRY. We can show that abnormal interchange happens… CONTINUE READING
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