Abnormal Vitamin Levels in Patients Receiving Home Total Parenteral Nutrition

  title={Abnormal Vitamin Levels in Patients Receiving Home Total Parenteral Nutrition},
  author={Vida Mikalunas and Kathleen Fitzgerald and Halina Rubin and R. Mccarthy and Robert M. Craig},
  journal={Journal of Clinical Gastroenterology},
The administration of multivitamins to patients receiving home parenteral nutrition (HPN) was decreased from once daily to three times weekly during the parenteral multivitamin shortage in 1997. Blood vitamin levels were measured to examine whether the decrement in the infused vitamins affected the levels. Six patients with normal renal and liver function, receiving HPN for 6 months to 10 years, were studied 6 months after the institution of 10 mL of multivitamins thrice weekly. Two patients… 

Serum vitamins in adult patients with short bowel syndrome receiving intermittent parenteral nutrition.

The findings suggest that the administered vitamins were not sufficient for the intermittent PN scheme and that individual adjustments are needed depending on the patient's vitamin status.

The Nutritional Aspects of Intestinal Failure Therapy

The goal of this chapter is to outline the nutritional aspects of intestinal failure management highlighting the specific aspects that make it such a challenging condition.

Monitoring long-term parenteral nutrition

Purpose of review This review discusses the monitoring aimed at achieving good long-term outcomes in people dependent on home parenteral nutrition (HPN). Recent findings There have been recent

Australasian society for parenteral and enteral nutrition (AuSPEN) adult vitamin guidelines for parenteral nutrition.

It appears that the parenteral multivitamin preparations presently available in Australia and NZ are to sufficient avoid deficiency without causing toxicity in most clinical situations for adults receiving PN when provided regularly as part of the PN prescription.

ESPEN guidelines on chronic intestinal failure in adults.

A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products.

  • V. VanekP. Borum C. Valentine
  • Medicine
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
  • 2012
The parenteral multi-trace element (TE) preparations that are commercially available in the U.S. require significant modifications and should be made available for treatment of patients with vitamin D deficiency unresponsive to oral vitamin D supplementation.

Home parenteral nutrition support for intestinal failure.

Comparison of a Direct and Indirect Method for Measuring Flavins- Assessing Flavin Status in Patients Receiving Total Parenteral Nutrition

The HPLC method was used to assess prevalence of flavin deficiency in total parenteral nutrition (TPN) patients and was superior to the EGRAC assay for assessing flavin status.

Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review

It is considered that neurological side effects due to vitamin B6 intake are rare and only occur with high daily doses and/or longer treatment duration, and the benefit-risk ratio of high-dose treatment with neurotropic B vitamins in indications like PN is considered advantageous, particularly if dosing recommendations are followed and serum levels monitored.

Neurologic aspects of multiple organ transplantation.



Treatment effects of parenteral vitamins in total parenteral nutrition patients.

Standard parenteral vitamin therapy leads to marginal improvement in abnormally low pre-TPN vitamin levels, and the prevalence of abnormal vitamin levels in this population is high, with a significantly greater percent increase in vitamin A, C, and pyridoxine levels.

Plasma vitamin levels in patients on prolonged total parenteral nutrition.

According to the plasma concentrations of the vitamins studied it would appear that the commercial vitamin preparations used in this study are inadequate in maintaining optimal vitamin status.

Vitamin requirements in patients receiving total parenteral nutrition.

This study represents an initial attempt to define intravenous vitamin requirements in adult patients receiving total parenteral nutrition (TPN). We have investigated two different vitamin

Water soluble vitamin requirements in home parenteral nutrition patients.

The results suggest that in long term home parenteral nutrition patients these five vitamins can safely be given twice weekly, rather than daily, and that short bowel patients who maintain their weight without intravenous calories and protein also assimilate adequate amounts of these proximally absorbed water soluble vitamins from their diet.

Blood vitamin levels of long-term adult home total parenteral nutrition patients: the efficacy of the AMA-FDA parenteral multivitamin formulation.

The AMA-FDA formula given daily maintained blood levels above the lower normal limits for most of its constituent vitamins and vitamin D metabolites for the great majority of stable home total parenteral nutrition adults with unexplained occasional exceptions.

Vitamin status during total parenteral nutrition.

Plasma vitamin A, E, and folate concentrations and vitamin B6 status improved significantly during TPN, and the adequacy of vitamin replacement and the monitoring of vitamin status During TPN is discussed.

Thiamin and pyridoxine requirements during intravenous hyperalimentation.

Two new vitamin combinations, type B (from commercial products) and type C (a convenient and easily administered combination produced at the hospital) were developed in order to provide the normal dietary allowances and at the same time eliminate any harmful side-effects.

Biotin deficiency in an adult during home parenteral nutrition.

One child with short-bowel syndrome has been described in which signs ofBiotin deficiency appeared in association with parenteral nutrition and antibiotic therapy, and these signs reversed with administration of 10 mg of biotin a day.

Effect of Intralipid, amino acids, container, temperature, and duration of storage on vitamin stability in total parenteral nutrition admixtures.

The presence of Intralipid resulted in higher levels of vitamin E due to IntralIPid's inherent vitamin E content; no other experimental conditions affected vitamin E.