Abnormal Transient Pupillary Light Reflex in Individuals with Autism Spectrum Disorders

  title={Abnormal Transient Pupillary Light Reflex in Individuals with Autism Spectrum Disorders},
  author={Xiaofei Fan and Judith H. Miles and Nicole Takahashi and Gang Yao},
  journal={Journal of Autism and Developmental Disorders},
Computerized binocular infrared pupillography was used to measure the transient pupillary light reflex (PLR) in both children with autism spectrum disorders (ASDs) and children with typical development. We found that participants with ASDs showed significantly longer PLR latency, smaller constriction amplitude and lower constriction velocity than children with typical development. The PLR latency alone can be used to discriminate the ASD group from the control group with a cross-validated… 

Atypical Pupillary Light Reflex in Individuals with Autism

The results showed that the ASD group had significantly longer PLR latency, reduced relative constriction amplitude, and lesser constriction/redilation time than those of the TD group, and similar atypical PLR parameters were observed in the NDD group.

Enhanced pupillary light reflex in infancy is associated with autism diagnosis in toddlerhood

It is shown that on average the relative constriction of the pupillary light reflex is larger in 9–10-month-old high risk infant siblings who receive an ASD diagnosis at 36 months, compared both to those who do not and to low-risk controls.

Age-dependent pupillary light reflex parameters in children

  • C. DaluwatteJ. Miles G. Yao
  • Medicine
    2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 2012
PLR has the potential to be used as a simple noninvasive tool for monitoring neurodevelopment in children, and a significant and consistent age effect was found on PLR latency in children younger than 10 years old.

Atypical pupillary light reflex in 2–6‐year‐old children with autism spectrum disorders

The base pupil radius, PLR latency, and constriction time showed a significant age‐related trend in both the ASD and TD groups, and may suggest disrupted autonomic controls in children with ASD.

A longitudinal study of pupillary light reflex in 6- to 24-month children

The experimental data acquired in this study revealed not only general age-related PLR changes in infants and toddlers, but also different PLRs in children with a higher risk of ASD.

Hypersensitive pupillary light reflex in infants at risk for autism

It is established that infant siblings of children with autism have hypersensitive pupillary light reflexes, a result which supports the view that altered sensory processing in infancy is associated with elevated autism risk.

Using Pupillometry to Assess the Atypical Pupillary Light Reflex and LC-NE System in ASD

  • G. Lynch
  • Biology, Psychology
    Behavioral sciences
  • 2018
This review draws from animal models of ASD demonstrating disruption of cranial motor nuclei and brain imaging studies examining arousal and the influence of the locus coeruleus norepinephrine (LC-NE) system on the pupillary response.

Pupillary Response and Phenotype in ASD: Latency to Constriction Discriminates ASD from Typically Developing Adolescents

Results confirmed this measure's sensitivity within a subtype of ASD in later stages of development, serving as a correlate of neural activity within the locus–coeruleus norepinephrine (LC–NE) system.



Visual Scanning and Pupillary Responses in Young Children with Autism Spectrum Disorder

Visual scanning responses to landscapes had a negative correlation with the Behavior subscale of the Autism Diagnostic Observation Schedule-Generic for the ASD group and pupillary constriction to children's faces was shown, while control groups showed pupillary dilation.

Larger tonic pupil size in young children with autism spectrum disorder.

The symptoms of Autism Spectrum Disorder (ASD) have been suggested to manifest from atypical functioning of the autonomic nervous system (ANS), leading to altered arousal and atypical processing of

Pupillary light reflex latency in patients with multiple sclerosis.

Sex-specific lateralization of contraction anisocoria in transient pupillary light reflex.

Evidence that contraction anisocoria is more laterally asymmetric in males than in females is provided, which provides evidence that the effects of sex were related to the ambient light level and stimulus intensity.

Naso-temporal asymmetry and contraction anisocoria in the pupillomotor system

The nasal retina was significantly more sensitive than the temporal retina, and the direct pupillary reactions were significantly larger than the consensual reactions, which suggest an input of temporal retina to both sides of the pretectum.

Neuroanatomy of autism

Neuropathological findings in autism.

It is anticipated that future neuropathological studies hold great promise, especially as new techniques such as design-based stereology and gene expression are increasingly implemented and combined, larger samples are analysed, and younger subjects free of comorbidities are investigated.

Inequality of the direct and consensual light reflexes in normal subjects.

Anisocoria in darkness and during reflex responses to unilateral light stimulation was studied in 150 normal subjects with television pupillometry and it was concluded that a small degree of CONTRACTION ANISOCORIA is normal.

The cerebellar control of the pupillary light reflex in the cat

Reduced cardiac parasympathetic activity in children with autism