Abnormal Tau phosphorylation of the Alzheimer-type also occurs during mitosis.

@article{Delobel2002AbnormalTP,
  title={Abnormal Tau phosphorylation of the Alzheimer-type also occurs during mitosis.},
  author={Patrice Delobel and St{\'e}phane Flament and Malika Hamdane and Christel Mailliot and Aminu Sambo and S{\'e}verine B{\'e}gard and Nicolas Sergeant and Andr{\'e} Delacourte and J Vilain and Luc Bu{\'e}e},
  journal={Journal of neurochemistry},
  year={2002},
  volume={83 2},
  pages={412-20}
}
In Alzheimer's disease, neurofibrillary degeneration results from the aggregation of abnormally phosphorylated Tau proteins into filaments and it may be related to the reactivation of mitotic mechanisms. In order to investigate the link between Tau phosphorylation and mitosis, Xenopus laevis oocytes in which most of the M-phase regulators have been discovered were used as a cell model. The human Tau isoform htau412 (2+3-10+) was microinjected into prophase I oocytes that were then stimulated by… CONTINUE READING

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