Abnormal T2 relaxation time in the cerebellar vermis of adults sexually abused in childhood: potential role of the vermis in stress-enhanced risk for drug abuse

  title={Abnormal T2 relaxation time in the cerebellar vermis of adults sexually abused in childhood: potential role of the vermis in stress-enhanced risk for drug abuse},
  author={Carl M. Anderson and Martin H. Teicher and Ann Polcari and Perry F. Renshaw},

Cerebellar Lingula Size and Experiential Risk Factors Associated with High Levels of Alcohol and Drug Use in Young Adults

Physical maltreatment was observed to interact with cerebellar morphology resulting in a strong association with alcohol and substance use, and Lingula thickness may represent a novel, experientially sensitive, phenotypic risk factor for enhanced alcohol and drug use that perhaps modulates sensitivity to these agents.

Neuroimaging of child abuse: a critical review

The better controlled studies that show a direct correlation between childhood abuse and brain measures suggest that the most prominent deficits associated with early childhood abuse are in the function and structure of lateral and ventromedial fronto-limbic brain areas and networks that mediate behavioral and affect control.

Developmental differences in childhood motor coordination predict adult alcohol dependence: proposed role for the cerebellum in alcoholism.

Relationships found between adult alcoholism and early delays in motor development offer support for the theory that cerebellar deficits may play a causal role in the addiction process.

Early-life stress induces long-term morphologic changes in primate brain.

Peer-rearing during infancy induces enlargement in stress-sensitive brain regions that may be a structural phenotype for increased risk of stress-related neuropsychiatric disorders in human beings.

Neurobiological Consequences of Early Stress and Childhood Maltreatment: Are Results from Human and Animal Studies Comparable?

Preclinical studies on the effects of exposure to early life stress can demonstrate causality, and can enrich the understanding of the clinical research if they hypothesize that the consequences of early abuse are predominantly mediated through the induction of stress responses.

Neuropsychological and neuroimaging studies associated with emotional stress during childhood and adolescence/Estudos neuropsicologicos e de neuroimagem associados ao estresse emocional na infancia e adolescencia

Background: Childhood and adolescence are relevant periods for the brain maturation process. Experiences in early life have an important influence on adults patterns of behavior. Objective: To



Preliminary Evidence for Abnormal Cortical Development in Physically and Sexually Abused Children Using EEG Coherence and MRI a

It is hypothesized that early childhood abuse or trauma could affect the development of the cerebral cortex and limbic during childhood and result in neurobiological abnormalities responsible for subsequent psychiatric disorders.

Functional deficits in basal ganglia of children with attention-deficit/hyperactivity disorder shown with functional magnetic resonance imaging relaxometry

A new functional magnetic resonance imaging procedure (T2 relaxometry) was developed to indirectly assess blood volume in the striatum (caudate and putamen) of boys 6–12 years of age in steady-state conditions and found boys with attention-deficit/hyperactivity disorder had higher T2 relaxation time measures in the putamen bilaterally than healthy control subjects.

Increased prevalence of electrophysiological abnormalities in children with psychological, physical, and sexual abuse.

Increased electrophysiological abnormalities were found in abused patients compared with non-abused patients, which may support the hypothesis that early abuse alters brain development, particularly limbic structures.

The role of the cerebellum in affect and psychosis

Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorder.

Findings in this study confirm previous findings for boys in the posterior-inferior lobules of the cerebellar vermis for boys with attention-deficit/hyperactivity disorder in girls with ADHD.

Anterior cerebellar vermal stimulation: Effect on behavior and basal forebrain neurochemistry in rat

Hippocampal volume in women victimized by childhood sexual abuse

The observed relationship between symptom severity and hippocampal volume suggests that mesial temporal lobe dysfunction may directly mediate certain aspects of PTSD and dissociative disorder symptomatology.