Abnormal T cell responses to bacterial superantigens in Behçet's disease (BD).

@article{Hirohata1998AbnormalTC,
  title={Abnormal T cell responses to bacterial superantigens in Behçet's disease (BD).},
  author={Shunsei Hirohata and Tomohiro Hashimoto},
  journal={Clinical and experimental immunology},
  year={1998},
  volume={112 2},
  pages={
          317-24
        }
}
This study examines the nature of T cell hypersensitivity in BD. Highly purified T cells from 32 BD patients, from 29 rheumatoid arthritis (RA) patients and from 14 healthy individuals were cultured with various concentrations of Staphylococcal enterotoxins (SE) B and C1 in the presence of monocytes for 5 days, after which the production of interferon-gamma (IFN-gamma) was assessed. High concentrations of SE (1 ng/ml) stimulated BD T cells as well as control T cells to produce comparably high… CONTINUE READING
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