Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.

@article{Liu1993AbnormalTC,
  title={Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.},
  author={Cailong Liu and Ryuzo Ueda and Jian She and Jaime Ferrer Sancho and Baolin Wang and Greg Weddell and Janet Loring and Carole G. Kurahara and Erastus C. Dudley and Adrian C. Hayday},
  journal={The EMBO journal},
  year={1993},
  volume={12 12},
  pages={4863-75}
}
The T cell antigen receptor (TCR)-associated invariable membrane proteins (CD3-gamma, -delta, -epsilon and -zeta) are critical to the assembly and cell surface expression of the TCR/CD3 complex and to signal transduction upon engagement of TCR with antigen. Disruption of the CD3-zeta gene by homologous recombination resulted in a structurally abnormal thymus which primarily contained CD4- CD8- and TCR/CD3very lowCD4+CD8+ cells. Spleen and lymph nodes of CD3-zeta-/- mutant mice contained a… CONTINUE READING