Abnormal Spine Morphology and Enhanced LTP in LIMK-1 Knockout Mice

@article{Meng2002AbnormalSM,
  title={Abnormal Spine Morphology and Enhanced LTP in LIMK-1 Knockout Mice},
  author={Yanghong Meng and Yu Zhang and Vitali Tregoubov and Christopher G Janus and Luis Felipe S. Cruz and Mike Jackson and Wei-yang Lu and John F. MacDonald and Jay Y. Wang and Douglas L. Falls and Zhengping Jia},
  journal={Neuron},
  year={2002},
  volume={35},
  pages={121-133}
}
In vitro studies indicate a role for the LIM kinase family in the regulation of cofilin phosphorylation and actin dynamics. In addition, abnormal expression of LIMK-1 is associated with Williams syndrome, a mental disorder with profound deficits in visuospatial cognition. However, the in vivo function of this family of kinases remains elusive. Using LIMK-1… CONTINUE READING