Abnormal Schwann Cell-Axon Interactions in CMT Neuropathies: The Effects of Mutant Schwann Cells on the Axonal Cytoskeleton and Regeneration-Associated Myelination.

@article{Sahenk1999AbnormalSC,
  title={Abnormal Schwann Cell-Axon Interactions in CMT Neuropathies: The Effects of Mutant Schwann Cells on the Axonal Cytoskeleton and Regeneration-Associated Myelination.},
  author={Zarife Sahenk},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={883 1},
  pages={415-426}
}
Preferential distal axonal loss is a common feature of Charcot-Marie-Tooth (CMT) hereditary neuropathies. The general hypothesis tested here is that the axonal loss in these disorders is due to perturbed Schwann cell-axon interactions resulting from primary Schwann genetic defects. The nerve xenograft model was used to study the local influence of mutant Schwann cells derived from patients on axonal properties and the regeneration-associated myelination process. Sural nerve segments from… CONTINUE READING
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