Abnormal Platelet Trace Amine Profiles in Migraine With and Without Aura

@article{Dandrea2006AbnormalPT,
  title={Abnormal Platelet Trace Amine Profiles in Migraine With and Without Aura},
  author={Giovanni D'andrea and Franco Granella and Massimo Leone and Francesco Perini and Angelo Farruggio and Gennaro Bussone},
  journal={Cephalalgia},
  year={2006},
  volume={26},
  pages={968 - 972}
}
Trace amines, including tyramine, octopamine and synephrine, are closely related to classic biogenic amines. In one study, where these substances were found elevated in plasma of migraineurs, it was hypothesized that trace amine metabolism is deranged in migraine. To confirm these findings, we studied, using a multichannel electrochemical high-performance liquid chromatography system, the concentrations of trace amines in platelets of migraine without aura (MoA) and migraine with aura (MA… Expand
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References

SHOWING 1-10 OF 25 REFERENCES
Elevated levels of circulating trace amines in primary headaches
TLDR
The hypothesis that disorders of biogenic amine metabolism may be a characteristic biochemical trait in primary headache sufferers suggests that they may reflect sympathetic or hypothalamic dysfunction. Expand
Relationships between headache and amine changes after administration of reserpine to migrainous patients.
TLDR
Spontaneous migraine is not easy to study biochemically, as the frequency of attacks is of only limited predictability and may decrease when patients are hospitalized and subjected to the attention necessary for biochemical investigation. Expand
Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators
  • M. D. Berry
  • Chemistry, Medicine
  • Journal of neurochemistry
  • 2004
TLDR
Previous studies showing responses to physiologically relevant concentrations of trace amines are reviewed, along with those showing a reciprocal relationship between trace amine levels and fluctuations in basal monoaminergic tone, and it is hypothesized that the traceAmines function as endogenous neuromodulators of classical monoamine neurotransmitters. Expand
Occurrence, transport, and storage of octopamine in human thrombocytes
TLDR
3H‐octopamine was found to be accumulated in human platelets, achieving a maximum concentration gradient of 30:1, and these octopamine levels are in the range of those reported for platelet norepinephrine and epinephrine. Expand
HPLC electrochemical detection of trace amines in human plasma and platelets and expression of mRNA transcripts of trace amine receptors in circulating leukocytes
TLDR
Although baseline plasma levels of octopamine tyramine or synephrine may vary among healthy individuals, the observation that platelets store and actively release these trace amines suggests that they may be effectors involved in platelet-mediated signaling events in the bloodstream. Expand
Evidence for an altered dopamine‐hydroxylase activity in migraine and tension‐type headache
TLDR
The findings suggest that patients with migraine and tension‐type headache have a sympathetic hypofunction that may play an important role in the pathogenesis. Expand
Event-Related Slow Potentials and Associated Catecholamine Function in Migraine
TLDR
The results suggested that migraine without aura may involve dynamic shifts in the function of both norepinephrine and dopamine responsive neurons and pathophysiology of migraine with aura is less dependent on catecholamine imbalance (nore Pinephrine alone affected); these pathophysiological mechanisms are most prevalent in or restricted to posterior cortical regions but may be modulated by brainstem mechanisms. Expand
Evidence for allelic association of the dopamine β-hydroxylase gene (DBH) with susceptibility to typical migraine
TLDR
Polymorphisms within the dopamine beta-hydroxylase (DBH) gene, serotonin transporter gene (SERT), and dopamine receptor gene (DRD2) were tested and provided evidence for allelic association of the DBH gene with typical migraine susceptibility and indicate that further research into the role of theDBH gene in the etiology of migraine is warranted. Expand
Trace amines: Identification of a family of mammalian G protein-coupled receptors
  • B. Borowsky, N. Adham, +14 authors C. Gerald
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
TLDR
Using a degenerate PCR approach, 15 G protein-coupled receptors (GPCR) from human and rodent tissues are identified and it is demonstrated that two of these receptors bind and/or are activated by trace amines. Expand
Octopamine in invertebrates
  • T. Roeder
  • Biology, Medicine
  • Progress in Neurobiology
  • 1999
TLDR
This work has focused the interest on octopamine receptors from molluscs and insects believed to be good targets for highly specific insecticides as they are not found in vertebrates and four of them could be distinguished using pharmacological tools. Expand
...
1
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