Abnormal Pap smears with negative follow‐up biopsies: Improving cytohistologic correlations

@article{Bewtra2003AbnormalPS,
  title={Abnormal Pap smears with negative follow‐up biopsies: Improving cytohistologic correlations},
  author={Chhanda Bewtra and Muhammad Pathan and H. Hashish},
  journal={Diagnostic Cytopathology},
  year={2003},
  volume={29}
}
A review of the literature noted 11–16% discrepancy rates in cytology and histology diagnoses. We collected 358 cases with abnormal cytology and matching cervical biopsies. There were 123 (30%) discrepant pairs, of which 34 (27%) had negative biopsies following Papanicolaou (Pap) smears with squamous intraepithelial lesions (SIL). These constituted our study group. All biopsies were obtained within an average of 5 wk after Pap smears (range, 0–18 wk). After confirming original diagnoses, all… Expand
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References

SHOWING 1-4 OF 4 REFERENCES
Cytologic/histologic correlation for quality control in cervicovaginal cytology. Experience with 1,582 paired cases.
TLDR
The results of testing for human papillomavirus DNA by in situ hybridization were helpful in arbitrating some diagnositic disagreements. Expand
Cervical biopsy-cytology correlation. A College of American Pathologists Q-Probes study of 22 439 correlations in 348 laboratories.
TLDR
Current statistical expectations for cervical cytology-biopsy correlation, reasons for noncorrelation, and recommendations for quality improvement are defined and provided. Expand
Cervical biopsy/cytology correlation data can be collected prospectively and shared clinically
TLDR
Of 3,486 cases reviewed, 3,229 cases were satisfactory for correlation studies, and Concordant results were found in 86.9%. Expand
Prospective correlation of cervicovaginal cytologic and histologic specimens.
TLDR
An effective, prospective, computer-guided method of correlation is reported, reporting an effective capture of cases for correlation, minimization of errors before diagnoses are released to clinicians and patients, and internal standardization of diagnostic criteria. Expand