Abnormal Pap smears with negative follow‐up biopsies: Improving cytohistologic correlations

  title={Abnormal Pap smears with negative follow‐up biopsies: Improving cytohistologic correlations},
  author={Chhanda Bewtra and Muhammad Pathan and H. Hashish},
  journal={Diagnostic Cytopathology},
A review of the literature noted 11–16% discrepancy rates in cytology and histology diagnoses. We collected 358 cases with abnormal cytology and matching cervical biopsies. There were 123 (30%) discrepant pairs, of which 34 (27%) had negative biopsies following Papanicolaou (Pap) smears with squamous intraepithelial lesions (SIL). These constituted our study group. All biopsies were obtained within an average of 5 wk after Pap smears (range, 0–18 wk). After confirming original diagnoses, all… Expand
Clinical Factors That Predict Discrepancy between Cervical Cytology and Colposcopically Directed Biopsies
This study identifies several variables associated with CC/CB discrepancies that are important for a rigorous multi-disciplinary quality assurance effort. Expand
Pap test accuracy and severity of squamous intraepithelial lesion.
Cytology is a sufficiently sensitive test for detection of cervical lesions and can be used as a primary testing tool to triage in estimating the presence and grade of cervical disease against the reference standard of histopathology. Expand
Evaluation of the consistency ratios of cervical smear, cervical biopsy and conization results.
Smear technique has a serious discrepancy and under-diagnosis problem when its results are compared with biopsy and LEP, and the consistency between smear and LEEP results appears to improve with age. Expand
Discordance between Cytology and Biopsy Histology of the Cervix: What to Consider and What to Do
A retrospective evaluation of 431 patients who presented with colposcopic indication for cervical biopsy between 2003 and 2007 found cytology demonstrated a sensitivity and specificity of 87.3 and 71.0%, respectively. Expand
Human Papillomavirus Detection by PCR Assay in a Large Series of High-Grade Squamous Intraepithelial Lesions with Cytohistological Correlation and Follow-Up
HPVs are the precursors of invasive cervical carcinomas and are generally associated with the integration of mucosotropic human papillomavirus (HPV) DNA into the host cell genome and the pathogenic relevance of HPV strain 18 may be greater than previously assumed. Expand
Cytologic‐histologic correlation
Overall improvement appeared to be driven largely by improvement in preanalytic Papanicolaou (Pap) test sampling, because longer institutional participation also was associated with improved sampling sensitivity. Expand
A LEEP Cervical Conization Is Rarely Indicated for a Two-Step Discrepancy
A LEEP cone is rarely indicated for the evaluation of a 2-step discrepancy between cytological and histological findings and a randomized trial of this finding is warranted. Expand
Quality improvement opportunities in gynecologic cytologic-histologic correlations: findings from the College of American Pathologists Gynecologic Cytopathology Quality Consensus Conference working group 4.
Preliminary consensus statements developed by working groups using results from surveys and literature review are presented to document existing practices in gynecologic cytologic-histologic correlation, to develop consensus statements on appropriate practices, to explore standardization, and to suggest improvement in these practices. Expand
Cervical cytology/histology discrepancy: a 4‐year review of patient outcome
E. L. Moss, A. Moran, G. Douce, J. Parkes, R. Todd and C. W. Redman are among those who have died in the line of duty since World War Two. Expand


Cytologic/histologic correlation for quality control in cervicovaginal cytology. Experience with 1,582 paired cases.
The results of testing for human papillomavirus DNA by in situ hybridization were helpful in arbitrating some diagnositic disagreements. Expand
Cervical biopsy-cytology correlation. A College of American Pathologists Q-Probes study of 22 439 correlations in 348 laboratories.
Current statistical expectations for cervical cytology-biopsy correlation, reasons for noncorrelation, and recommendations for quality improvement are defined and provided. Expand
Cervical biopsy/cytology correlation data can be collected prospectively and shared clinically
Of 3,486 cases reviewed, 3,229 cases were satisfactory for correlation studies, and Concordant results were found in 86.9%. Expand
Prospective correlation of cervicovaginal cytologic and histologic specimens.
An effective, prospective, computer-guided method of correlation is reported, reporting an effective capture of cases for correlation, minimization of errors before diagnoses are released to clinicians and patients, and internal standardization of diagnostic criteria. Expand