Abnormal Measles-Mumps-Rubella Antibodies and CNS Autoimmunity in Children with Autism

@article{Singh2002AbnormalMA,
  title={Abnormal Measles-Mumps-Rubella Antibodies and CNS Autoimmunity in Children with Autism},
  author={V. Singh and S. X. Lin and E. Newell and C. Nelson},
  journal={Journal of Biomedical Science},
  year={2002},
  volume={9},
  pages={359 - 364}
}
Autoimmunity to the central nervous system (CNS), especially to myelin basic protein (MBP), may play a causal role in autism, a neurodevelopmental disorder. [...] Key Method Using serum samples of 125 autistic children and 92 control children, antibodies were assayed by ELISA or immunoblotting methods. ELISA analysis showed a significant increase in the level of MMR antibodies in autistic children. Immunoblotting analysis revealed the presence of an unusual MMR antibody in 75 of 125 (60%) autistic sera but not…Expand
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