Abnormal Fronto-striatal Connectivity in Children with Histories of Early Deprivation: A Diffusion Tensor Imaging Study

  title={Abnormal Fronto-striatal Connectivity in Children with Histories of Early Deprivation: A Diffusion Tensor Imaging Study},
  author={Michael E. Behen and Otto Muzik and Anita Saporta and Benjamin J. Wilson and Darshan Pai and J. Hua and Harry T. Chugani},
  journal={Brain Imaging and Behavior},
An Inattentive/Overactive (I/O) behavioral phenotype has been reported in a significant percentage of children raised from birth in orphanages. While a number of studies have identified both functional and structural brain abnormalities in children raised from birth in orphanages, no published studies have evaluated potential neural correlates of the I/O phenotype. We applied diffusion tensor imaging (DTI) to 15 pre-teen children raised in orphanages in Eastern Europe or Asia and later adopted… 
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