Abnormal Fhit protein expression and high frequency of microsatellite instability in sporadic colorectal cancer.

@article{Sarli2004AbnormalFP,
  title={Abnormal Fhit protein expression and high frequency of microsatellite instability in sporadic colorectal cancer.},
  author={Leopoldo Sarli and Lorena Bottarelli and Cinzia Azzoni and Nicoletta Campanini and Gabriella Di Cola and Giovanni Bader and Domenico Rosario Iusco and Carlo Salvemini and G. Caruso and Enrico Donadei and Silvia Pizzi and Tiziana D'adda and Costi Renato and Luigi Roncoroni and Cesare Bordi},
  journal={European journal of cancer},
  year={2004},
  volume={40 10},
  pages={
          1581-8
        }
}

• Leopoldo Sarli, Lorena Bottarelli, +12 authors Cesare Bordi
• Published 2004 in European journal of cancer

The role of Fhit protein in the oncogenesis of colorectal cancer is still in debate. Recent studies have revealed that reduced Fhit protein expression is associated with a deficiency of the mismatch repair protein. One hundred and twenty unselected patients who underwent curative resection for sporadic colorectal cancer in a three-year period were evaluated for microsatellite instability (MSI) using six microsatellite markers, and for the presence of Fhit and mismatch repair (MMR) proteins… CONTINUE READING

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