Abnormal Expression Pattern of the IL-2 Receptor β-Chain on CD4+ T Cells in ANCA-Associated Vasculitis

@inproceedings{Wilde2014AbnormalEP,
  title={Abnormal Expression Pattern of the IL-2 Receptor β-Chain on CD4+ T Cells in ANCA-Associated Vasculitis},
  author={Benjamin G. Wilde and Andr{\'e} Hoerning and Andreas Kribben and Oliver Witzke and Sebastian Conrad Johannes Dolff},
  booktitle={Disease markers},
  year={2014}
}
BACKGROUND/AIM ANCA-associated vasculitis (AAV) is a small-vessel vasculitis of autoimmune origin. In addition to autoantibodies, T cells have a pivotal pathophysiological role in this disease. T-cell homeostasis and immune tolerance critically depend on IL-2 and its receptor expressed by T cells. In this study, we investigated the IL-2 receptor (IL-2r) expression on CD4(+) T cells in AAV. METHODS Thirty patients with AAV and 15 age-matched healthy controls (HC) were enrolled. T cells from… CONTINUE READING

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