Abnormal Electroretinogram from a Drosophila Mutant

  title={Abnormal Electroretinogram from a Drosophila Mutant},
  author={Derek Cosens and Aubrey Manning},
THE use of behavioural mutants of Drosophila to elucidate functions of the nervous system has produced several nonphototactic mutants snowing abnormality in the recorded waveform of the electroretinogram (ERG)1,2. We are working with a mutant strain of D. melanogaster which, though behaving phototactically positive in a T-maze under low ambient light, is visually impaired and behaves as though blind in a simple optomotor apparatus where normal, wild-type flies will orientate to visual cues3,4… Expand

Paper Mentions

Blindness in a Drosophila mutant
A comparison of mutant ERG pattern with that of the wildtype suggests that the blindness relates to receptor repolarization which occurs in the mutant receptor during intense light adaptation, and the time course of dark adaptation would appear to support this conclusion. Expand
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The eventual aim is to learn how the action of particular genes programs into the animal such unknown mechanisms as those having to do with the formation of nerve connections and those involved in phototransduction are learned. Expand
Molecular basis of an inherited retinal defect in Drosophila.
Fruitflies carrying the autosomal recessive mutation transient receptor potential are blind in bright light because the receptor potential of such a mutant decays almost completely during an intense stimulus, consistent with the notion that the mutation alters the DNA sequence in a region containing signals necessary for the expression of the gene. Expand
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Results lend strong support to the notion that PGM is initiated by a light-evoked depolarization of the receptor membrane, i.e., the receptor potential, but under certain experimental conditions, the receptor possibles failed to induce PGM in the trp mutant. Expand
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A method for measuring the influence of light on pupation site preferences, PSP, of late-third-instar Drosophila is described and it is hypothesized that the step controlled by the norpA locus is common to the photoreceptors of both larvae and adult flies. Expand
Proper function of the drosophila trp gene product during pupal development is important for normal visual transduction in the adult
The trp protein is a novel photoreceptor membrane-associated protein, that this protein is not required for the occurrence of bumps but is necessary for adaptation, and that proper function of the trp gene product during pupal development is important for normal visual transduction in the adult. Expand
TRP Channels in Vision
The transient receptor potential (TRP) field began (for reviews see Minke, 2010; Montell, 2011; Hardie, 2011) with the analysis of a spontaneously formed Drosophila mutant showing transient, ratherExpand
Experimental confinement of the transient receptor potential to the peripheral retinula cells in the trp mutant Drosophila: What it tells us about the mutation and visual function
Recovery of the peripheral receptors' sensitivity in ambient light conditions which would render them insensitive by expression of the phenotype is paradoxical and allows a “wavelength effectivity” curve to be constructed which identifies the involvement of the rhodopsin. Expand
Chemical excitation and inactivation in photoreceptors of the fly mutants trp and nss
The results suggest that the fly phototransduction pathway involves a feedback regulatory loop, which branches subsequent to InsP3 production and regulates guanine nucleotide-binding protein (G protein)- phospholipase C activity. Expand
A comparative study of specific chromatic adaptation of the wildtype and trp mutant of Drosophila melanogaster
Blue-adaptation by isolating the activity of the central retinula cells confirms that the trp lesion affects these receptors also and recovery of sensitivity by application of orange light either during or after blue- Adaptation is different in w;trp flies from that in bw;cn flies and does not proceed as predicted from thetrp genotype. Expand


Abnormal Electroretinograms in Visual Mutants of Drosophila
Two mutants of Drosophila, tan and ebony, have normal eye pigments but show abnormalities in visual behaviour. Both show in their electroretinograms that the primary photoreception process occursExpand
Heritability and threshold determinations of the optomotor response in Drosophila melanogaster.
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The optomotor response to an illuminated, moving striped plate was measured in 104 flies from a wild type population of Drosophila melanogaster and the degree of displacement representing systematic differences between the strains was studied. Expand
Nonphototactic Mutants in a Study of Vision of Drosophila
Most of the nonphototactic mutants of Drosophila respond to light stimuli with normal electroretinograms. Mutants x-7 and tan, however, seem to represent mutants of the visual pathway. TheirExpand
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Drosophila possesses an inherited reflex response to a moving visual pattern which can be used to measure its capacity for intensity discrimination and its visual acuity at different illuminations.Expand