Abnormal Electroretinogram from a Drosophila Mutant

@article{Cosens1969AbnormalEF,
  title={Abnormal Electroretinogram from a Drosophila Mutant},
  author={Derek Cosens and Aubrey Manning},
  journal={Nature},
  year={1969},
  volume={224},
  pages={285-287}
}
THE use of behavioural mutants of Drosophila to elucidate functions of the nervous system has produced several nonphototactic mutants snowing abnormality in the recorded waveform of the electroretinogram (ERG)1,2. We are working with a mutant strain of D. melanogaster which, though behaving phototactically positive in a T-maze under low ambient light, is visually impaired and behaves as though blind in a simple optomotor apparatus where normal, wild-type flies will orientate to visual cues3,4… Expand

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Recovery of the peripheral receptors' sensitivity in ambient light conditions which would render them insensitive by expression of the phenotype is paradoxical and allows a “wavelength effectivity” curve to be constructed which identifies the involvement of the rhodopsin. Expand
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A comparative study of specific chromatic adaptation of the wildtype and trp mutant of Drosophila melanogaster
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Blue-adaptation by isolating the activity of the central retinula cells confirms that the trp lesion affects these receptors also and recovery of sensitivity by application of orange light either during or after blue- Adaptation is different in w;trp flies from that in bw;cn flies and does not proceed as predicted from thetrp genotype. Expand
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References

SHOWING 1-5 OF 5 REFERENCES
Abnormal Electroretinograms in Visual Mutants of Drosophila
Two mutants of Drosophila, tan and ebony, have normal eye pigments but show abnormalities in visual behaviour. Both show in their electroretinograms that the primary photoreception process occursExpand
Heritability and threshold determinations of the optomotor response in Drosophila melanogaster.
  • I. Siegel
  • Biology, Medicine
  • Animal behaviour
  • 1967
TLDR
The optomotor response to an illuminated, moving striped plate was measured in 104 flies from a wild type population of Drosophila melanogaster and the degree of displacement representing systematic differences between the strains was studied. Expand
Nonphototactic Mutants in a Study of Vision of Drosophila
Most of the nonphototactic mutants of Drosophila respond to light stimuli with normal electroretinograms. Mutants x-7 and tan, however, seem to represent mutants of the visual pathway. TheirExpand
THE VISUAL ACUITY AND INTENSITY DISCRIMINATION OF DROSOPHILA
  • S. Hecht, G. Wald
  • Mathematics, Medicine
  • The Journal of general physiology
  • 1934
Drosophila possesses an inherited reflex response to a moving visual pattern which can be used to measure its capacity for intensity discrimination and its visual acuity at different illuminations.Expand