Abnormal DNA repair in selenium-treated human cells.

  title={Abnormal DNA repair in selenium-treated human cells.},
  author={Khaled S Abul-Hassan and Bruce E. Lehnert and Lorraine Guant and Richard Maurice Walmsley},
  journal={Mutation research},
  volume={565 1},
Selenium (Se), a micronutrient and an environmental, a chemical and an industrial agent in many products, can have genotoxic effects as well as antimutagenic and/or anticarcinogenic properties, depending on its concentration and oxidation state. We investigated the cytotoxic response of human osteosarcoma (U2OS) cells to low doses of sodium selenite and assayed their resistivity to cisplatin treatment and their capacity to reactivate cisplatin-treated reporter system, whose repair occurs… CONTINUE READING

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