Abnormal Compartmentalization of Cartilage Matrix Components in Mice Lacking Collagen X: Implications for Function

@article{Kwan1997AbnormalCO,
  title={Abnormal Compartmentalization of Cartilage Matrix Components in Mice Lacking Collagen X: Implications for Function},
  author={Kin Ming Kwan and Michael K.M. Pang and Sheila X. Zhou and Soot Keng Cowan and Richard Kong and Tim Pfordte and Bjorn Reino Olsen and David O. Sillence and Patrick P. L. Tam and Kathryn Song Eng Cheah},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={136},
  pages={459 - 471}
}
There are conflicting views on whether collagen X is a purely structural molecule, or regulates bone mineralization during endochondral ossification. Mutations in the human collagen alpha1 (X) gene (COL10A1) in Schmid metaphyseal chondrodysplasia (SMCD) suggest a supportive role. But mouse collagen alpha1 (X) gene (Col10a1) null mutants were previously reported to show no obvious phenotypic change. We have generated collagen X deficient mice, which shows that deficiency does have phenotypic… CONTINUE READING
63 Extracted Citations
50 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 63 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 50 references

Altered matrix structure and bone density in collagen X null mice

  • K.S.E. Cheah, K. M. Kwan, +5 authors P.P.L. Tam.
  • Ann. NY Acad. Sci. In press.
  • 1995
1 Excerpt

Molecular biology of matrix vesicles

  • H. C. Anderson
  • Clin. Orthop. Rel. Res. 314:266–280.
  • 1995
3 Excerpts

Similar Papers

Loading similar papers…